Effects of Dense Granular Protein 6 (GRA6) Disruption on Neospora caninum Virulence
نویسندگان
چکیده
منابع مشابه
First Characterization of the Neospora caninum Dense Granule Protein GRA9
The obligate intracellular apicomplexan parasite Neospora caninum (N. caninum) is closely related to Toxoplasma gondii (T. gondii). The dense granules, which are present in all apicomplexan parasites, are important secretory organelles. Dense granule (GRA) proteins are released into the parasitophorous vacuole (PV) following host cell invasion and are known to play important roles in the mainte...
متن کاملGRA 14, a novel dense granule protein from Neospora caninum.
Dense granule protein (GRA) is a secreted protein in Neospora caninum and Toxoplasma gondii, which plays an important role in forming parasitophorous vacuole (PV) [1–4]. GRAs are thought to remodel and maintain the environment of the PV for intracellular survival and replication in T. gondii [5]. The precise function of GRAs is still unknown [6–9]. TgGRA14 protein is a new GRA protein that it i...
متن کاملVirulence assessment of a Neospora caninum isolate for inbred C57BL/6 mouse
Neospora caninum (N. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. In this study, we evaluate the virulence of a N. caninum isolate on mouse strain C57BL/6. Six groups of five mice C57BL/6 were intraperitoneally inoculated with 1 × l07, 1.5 × l07, 2 × l07, 3 × l07 and 4 × l07 tachyzoites and a control inoculum of DMEM, respectively. Cli...
متن کاملvirulence assessment of a neospora caninum isolate for inbred c57bl/6 mouse
neospora caninum (n. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. in this study, we evaluate the virulence of a n. caninum isolate on mouse strain c57bl/6. six groups of five mice c57bl/6 were intraperitoneally inoculated with 1 × l07, 1.5 × l07, 2 × l07, 3 × l07 and 4 × l07 tachyzoites and a control inoculum of dmem, respectively. cli...
متن کاملNeospora caninum and neosporosis
Neospora caninum is a protozoan cyst forming apicomplexan parasite that causes neosporosis, notably in cattle (Bos taurus) and domestic dogs (Canis familiaris) [1,2]. It is closely related to Toxoplasma gondii and has emerged as a major cause of reproductive failure in cattle worldwide [2]. The parasite was first described in a dog with encephalomyelitis and myositis [1] and was later described...
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ژورنال
عنوان ژورنال: Frontiers in Veterinary Science
سال: 2020
ISSN: 2297-1769
DOI: 10.3389/fvets.2020.562730